rna-dependent rna polymerase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4686	Simeprevir	TMC435,TMC-435350,Olysio	HCV Protease , SARS-CoV
	Simeprevir (TMC435) is a potent HCV NS3/4A protease inhibitor, and inhibits HCV replication with EC50 of 8 nM.		HCV Protease , SARS-CoV
T8972	FIT-039		Others , DNA/RNA Synthesis , CDK , HSV
	FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a pr...		Others , DNA/RNA Synthesis , CDK , HSV
T10493	Beclabuvir	BMS-791325	Others
	Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase. It inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 (IC50 < 28 nM).		Others
T6833	Favipiravir	T-705,6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide	Others , SARS-CoV , Influenza Virus , DNA/RNA Synthesis
	Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.		Others , SARS-CoV , Influenza Virus , DNA/RNA Synthesis
T3489	Dasabuvir	ABT-333	HCV Protease
	Dasabuvir (ABT-333) is a non-nucleoside inhibitor of the hepatitis C virus (HCV) non-structural protein 5B (NS5B), an RNA-dependent RNA polymerase, with potential activity against HCV. Upon administration and after intra...		HCV Protease
T27696	JTK-109	JTK109	HCV Protease
	JTK-109 is an inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor and inhibits G1b and G3a subgenomic replicons and recombinant enzymes.		HCV Protease
T15282	Filibuvir	PF-00868554	HCV Protease , DNA/RNA Synthesis
	Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM.		HCV Protease , DNA/RNA Synthesis
T1501	Rifabutin	LM-427,Ansamycin	HSP , DNA/RNA Synthesis , Antibacterial , Antibiotic
	Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin...		HSP , DNA/RNA Synthesis , Antibacterial , Antibiotic
T9617	RdRP-IN-2		SARS-CoV
	RdRP-IN-2 is a RNA dependent RNA polymerase (RdRp) inhibitor. It significantly inhibits SARS-CoV-2 RdRp with an IC50 of 41.2 µM.It also inhibits Feline coronavirus (FIPV) replication.		SARS-CoV
TQ0090	Nesbuvir	HCV-796	HCV Protease
	Nesbuvir is a selective hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent polymerase inhibitor.Nesbuvir has an IC50 of 9 nM against hepatocellular carcinoma cells containing 1b HCV replicons.		HCV Protease
T10491	Galidesivir	BCX4430,Immucillin-A	Others
	Galidesivir (BCX4430) is a broad-spectrum antiviral compound, an adenosine analog that inhibits viral RNA-dependent RNA polymerase (RdRp) activity.Galidesivir inhibits a wide range of RNA viral pathogens in vitro, and re...		Others
T1154	Rifaximin		DNA/RNA Synthesis , Antibacterial , Antibiotic
	Rifaximin is an orally administered, semi-synthetic, nonsystemic antibiotic derived from rifamycin SV with antibacterial activity. Rifaximin binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, inhibiting...		DNA/RNA Synthesis , Antibacterial , Antibiotic
T7766	Remdesivir	GS-5734	SARS-CoV , DNA/RNA Synthesis
	Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of viruses. Remdesivir is active against Ebola, SARS, and MERS viru...		SARS-CoV , DNA/RNA Synthesis
T8347	Rifamycin S		Reactive Oxygen Species , ROS , Antibacterial , Antibiotic
	Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria		Reactive Oxygen Species , ROS , Antibacterial , Antibiotic
T5003	Rifamycin sodium	Rifamycin sodium salt	Antibacterial , Antibiotic
	Rifamycin sodium (Rifamycin sodium salt) salt is an antibiotic that inhibits bacterial DNA-dependent RNA polymerase. It is effective against Gram-positive bacteria.		Antibacterial , Antibiotic
T77520	AOH1996		Apoptosis , DNA/RNA Synthesis
	AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).AOH1996 interferes with the interaction of PCNA with its ...		Apoptosis , DNA/RNA Synthesis
T79404	A09-003		Apoptosis , BCL , CDK
	A09-003 is a novel cell cycle protein-dependent kinase-9 CDK-9 inhibitor.A09-003 inhibits the proliferation of a variety of leukemia cell lines and inhibits the increase of leukemia sequence-1 protein in myeloid cells.A0...		Apoptosis , BCL , CDK
T14495	Baloxavir	Baloxavir acid,S-033447	Influenza Virus
	Baloxavir (S-033447) is a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.		Influenza Virus
T27260	Emivirine	MKC442,MKC-442,MKC 442,DRG-0302,DRG 0302,DRG0302	HIV Protease
	Emivirine (MKC-442) is a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.		HIV Protease
T27485	GSK-625433
	GSK-625433, a homochiral inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, has the ability to inhibit the polymerase of both HCV genotypes 1a and 1b.